Bis-propargyl-PEG4

• CAT Number: I014264
• CAS Number: 159428-42-9
• Molecular Formula: C14H22O5
• Molecular Weight: 270.32
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]prop-1-yne
• InChI: InChI=1S/C14H22O5/c1-3-5-15-7-9-17-11-13-19-14-12-18-10-8-16-6-4-2/h1-2H,5-14H2
• InChIKey: FCPHAZIYRMYSTF-UHFFFAOYSA-N
• SMILES: C#CCOCCOCCOCCOCCOCC#C

Bis-propargyl-PEG4(CAT:I014264) is a homobifunctional polyethylene glycol (PEG) linker containing two terminal propargyl (alkyne) groups separated by a tetraethylene glycol (PEG4) spacer. The terminal alkynes enable efficient copper-catalyzed azide–alkyne cycloaddition (CuAAC), commonly known as click chemistry, for covalent conjugation with azide-containing biomolecules or materials. The PEG4 backbone provides hydrophilicity, flexibility, and reduced steric hindrance, ensuring high reaction efficiency in aqueous environments. Bis-propargyl-PEG4 is widely applied in bioconjugation, polymer modification, nanomaterial functionalization, and drug delivery research, where controlled spacing and water solubility are essential. Its dual alkyne functionality makes it a versatile crosslinker for constructing multi-functional biomolecular assemblies.