Bis-propargyl-PEG3

• CAT Number: I016887
• CAS Number: 126422-58-0
• Molecular Formula: C12H18O4
• Molecular Weight: 226.27
• Purity: ≥95%
• Synonyms: 3-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]prop-1-yne
• InChI: InChI=1S/C12H18O4/c1-3-5-13-7-9-15-11-12-16-10-8-14-6-4-2/h1-2H,5-12H2
• InChIKey: PHRQSGRBGBTBAD-UHFFFAOYSA-N
• SMILES: C#CCOCCOCCOCCOCC#C

Bis-propargyl-PEG3(CAT: I016887) is a homobifunctional polyethylene glycol (PEG) linker featuring terminal propargyl (alkyne) groups connected by a three-unit PEG spacer. The terminal alkynes readily participate in copper-catalyzed or strain-promoted azide–alkyne cycloaddition (“click chemistry”), forming stable triazole linkages with azide-containing molecules. The PEG3 spacer provides hydrophilicity, molecular flexibility, and reduced steric hindrance, improving solubility and reaction efficiency in both aqueous and organic systems. Bis-propargyl-PEG3 is widely used in bioconjugation, crosslinking, surface modification, polymer functionalization, and nanotechnology, supporting the creation of multifunctional constructs. Its symmetrical structure makes it ideal for generating well-defined dual-modified biomolecules and advanced material assemblies.