Bis-PEG4-t-butyl ester

• CAT Number: I045411
• CAS Number: 2100306-53-2
• Molecular Formula: C20H38O8
• Molecular Weight: 406.51
• Purity: ≥95%
• Synonyms: tert-butyl 3-[2-[2-[2-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C20H38O8/c1-19(2,3)27-17(21)7-9-23-11-13-25-15-16-26-14-12-24-10-8-18(22)28-20(4,5)6/h7-16H2,1-6H3
• InChIKey: BEMRKFMWPQHBBR-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCOCCOCCOCCC(=O)OC(C)(C)C

Bis-PEG4-t-butyl ester (Cat No.: I045411) is a symmetric polyethylene glycol (PEG) linker containing two t-butyl ester-protected carboxylic acid groups connected by a PEG4 spacer (four ethylene glycol units). The PEG segment imparts hydrophilicity and flexibility, minimizing steric hindrance in chemical reactions. The t-butyl ester groups provide acid-labile protection, allowing controlled deprotection to yield free acids for subsequent coupling. This reagent is commonly used in the synthesis of multifunctional molecules, polymer modification, bioconjugation, and the preparation of drug delivery systems in chemical and biomedical research.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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