Bis-PEG3-t-butyl ester

• CAT Number: I045412
• CAS Number: 1611468-29-1
• Molecular Formula: C18H34O7
• Molecular Weight: 362.46
• Purity: ≥95%
• Synonyms: tert-butyl 3-[2-[2-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C18H34O7/c1-17(2,3)24-15(19)7-9-21-11-13-23-14-12-22-10-8-16(20)25-18(4,5)6/h7-14H2,1-6H3
• InChIKey: BIABJXAWGDLLJY-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCOCCOCCC(=O)OC(C)(C)C

Bis-PEG3-t-butyl ester (Cat No.: I045412) is a symmetric polyethylene glycol (PEG) linker composed of two t-butyl ester-protected carboxylic acid groups connected by a PEG3 spacer (three ethylene glycol units). The PEG chain enhances hydrophilicity, flexibility, and water solubility while reducing steric hindrance in coupling reactions. The t-butyl esters serve as acid-labile protecting groups, enabling controlled release of reactive carboxylic acids for further conjugation. This reagent is widely applied in bioconjugation, polymer modification, multifunctional molecule synthesis, and drug delivery system development in biomedical and chemical research.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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