Bis-PEG10-t-butyl ester

• CAT Number: I045414
• Molecular Formula: C32H62O14
• Molecular Weight: 670.83
• Purity: ≥95%
• Synonyms: tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C32H62O14/c1-31(2,3)45-29(33)7-9-35-11-13-37-15-17-39-19-21-41-23-25-43-27-28-44-26-24-42-22-20-40-18-16-38-14-12-36-10-8-30(34)46-32(4,5)6/h7-28H2,1-6H3
• InChIKey: SIGOVPKCEGADHD-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)OC(C)(C)C

Bis-PEG10-t-butyl ester (Cat No.: I045414) is a symmetric polyethylene glycol (PEG) linker containing two t-butyl ester-protected carboxylic acid groups connected by a PEG10 spacer (ten ethylene glycol units). The long PEG chain imparts excellent hydrophilicity, flexibility, and enhanced water solubility, while minimizing steric hindrance in coupling reactions. The t-butyl esters serve as acid-labile protecting groups, allowing controlled release of reactive carboxylic acids for further conjugation. This reagent is widely used in bioconjugation, polymer modification, multifunctional molecule synthesis, and the development of advanced drug delivery systems in biomedical research.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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