For research use only. Not for therapeutic Use.
BIP-135(CAT: R040970) is a potent and selective ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor, with IC50 values of 16 nM (GSK-3α) and 21 nM (GSK-3β). It demonstrates strong neuroprotective activity, enhancing survival motor neuron (SMN) protein expression in human SMA fibroblasts (25 μM, 72 h) with a bell-shaped dose-response profile. In oxidative stress models, BIP-135 (20 μM, 48 h) shows superior neuroprotection. In vivo, treatment (75 mg/kg i.p., P0–21) prolongs median survival in the Δ7 SMA knockout mouse model of spinal muscular atrophy, with no significant toxicity or weight loss, highlighting its promise in neurodegenerative disease research.
| CAS Number | 941575-71-9 |
| Synonyms | 3-(1-benzofuran-3-yl)-4-(5-bromo-1-methylindol-3-yl)pyrrole-2,5-dione |
| Molecular Formula | C21H13BrN2O3 |
| Purity | ≥95% |
| IUPAC Name | 3-(1-benzofuran-3-yl)-4-(5-bromo-1-methylindol-3-yl)pyrrole-2,5-dione |
| InChI | InChI=1S/C21H13BrN2O3/c1-24-9-14(13-8-11(22)6-7-16(13)24)18-19(21(26)23-20(18)25)15-10-27-17-5-3-2-4-12(15)17/h2-10H,1H3,(H,23,25,26) |
| InChIKey | QKQJCKAXFJBYKJ-UHFFFAOYSA-N |
| SMILES | CN1C=C(C2=C1C=CC(=C2)Br)C3=C(C(=O)NC3=O)C4=COC5=CC=CC=C54 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
