For research use only. Not for therapeutic Use.
Biotinylated-JQ1（Cat No.:I044141）is a derivative of the BET bromodomain inhibitor JQ1, modified with a biotin tag to enable affinity-based applications. Retaining high affinity for BET family proteins such as BRD2, BRD3, and BRD4, biotinylated-JQ1 is widely used in chemical biology to study protein–protein interactions, chromatin occupancy, and target engagement through techniques like pull-down assays and chromatin immunoprecipitation (ChIP). The biotin moiety allows for easy capture using streptavidin-conjugated beads or probes. This tool is instrumental in investigating epigenetic regulation, transcriptional control, and BET inhibitor mechanism-of-action in cancer and inflammatory disease research.
| CAS Number | 1635437-52-3 |
| Synonyms | 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[3-[2-[2-[3-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]propoxy]ethoxy]ethoxy]propyl]pentanamide |
| Molecular Formula | C39H53ClN8O6S2 |
| Purity | ≥95% |
| IUPAC Name | 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[3-[2-[2-[3-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]propoxy]ethoxy]ethoxy]propyl]pentanamide |
| InChI | InChI=1S/C39H53ClN8O6S2/c1-24-25(2)56-38-34(24)35(27-10-12-28(40)13-11-27)43-29(37-47-46-26(3)48(37)38)22-33(50)42-15-7-17-53-19-21-54-20-18-52-16-6-14-41-32(49)9-5-4-8-31-36-30(23-55-31)44-39(51)45-36/h10-13,29-31,36H,4-9,14-23H2,1-3H3,(H,41,49)(H,42,50)(H2,44,45,51)/t29-,30-,31-,36-/m0/s1 |
| InChIKey | HLZRRKIVMLXYEU-MSMWPWNWSA-N |
| SMILES | CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)NCCCOCCOCCOCCCNC(=O)CCCC[C@H]4[C@@H]5[C@H](CS4)NC(=O)N5)C6=CC=C(C=C6)Cl)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
