Biotin-PEG8-amine

• CAT Number: I016791
• CAS Number: 2183447-27-8
• Molecular Formula: C28H54N4O10S
• Molecular Weight: 638.81
• Purity: ≥95%
• Synonyms: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]pentanamide
• InChI: InChI=1S/C28H54N4O10S/c29-5-7-35-9-11-37-13-15-39-17-19-41-21-22-42-20-18-40-16-14-38-12-10-36-8-6-30-26(33)4-2-1-3-25-27-24(23-43-25)31-28(34)32-27/h24-25,27H,1-23,29H2,(H,30,33)(H2,31,32,34)/t24-,25-,27-/m0/s1
• InChIKey: KCEDJIKXCRNXKQ-KLJDGLGGSA-N
• SMILES: C1C2C(C(S1)CCCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCN)NC(=O)N2

Biotin-PEG8-amine(CAT: I016791) is a biotinylated linker featuring a terminal primary amine and a PEG8 spacer. The amine group enables efficient conjugation via amide bond formation with activated esters (e.g., NHS esters) or carboxylic acids, making it versatile for labeling peptides, proteins, and other amine-reactive biomolecules. The PEG8 chain provides excellent solubility, flexibility, and reduced steric hindrance, optimizing conjugation efficiency in aqueous systems. The biotin moiety binds strongly and specifically to streptavidin or avidin, facilitating detection, enrichment, and immobilization. Biotin-PEG8-amine is widely applied in chemical biology, proteomics, diagnostics, and drug discovery research for biotinylation and biomolecular interaction studies.