Biotin-PEG6-Thalidomide

• CAT Number: I015731
• CAS Number: 2144775-48-2
• Molecular Formula: C37H53N5O12S
• Molecular Weight: 791.91
• Purity: ≥95%
• Synonyms: 5-[(3aR,4R,6aS)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[2-[2-[2-[3-(1,3-dioxoisoindol-2-yl)-2,6-dioxopiperidin-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]pentanamide
• InChI: InChI=1S/C37H53N5O12S/c43-31(8-4-3-7-30-33-28(25-55-30)39-37(48)40-33)38-11-13-49-15-17-51-19-21-53-23-24-54-22-20-52-18-16-50-14-12-41-32(44)10-9-29(36(41)47)42-34(45)26-5-1-2-6-27(26)35(42)46/h1-2,5-6,28-30,33H,3-4,7-25H2,(H,38,43)(H2,39,40,48)/t28-,29?,30-,33-/m1/s1
• InChIKey: UCCXTWDQIINXHE-QSCAEMQVSA-N
• SMILES: C1CC(=O)N(C(=O)C1N2C(=O)C3=CC=CC=C3C2=O)CCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]4[C@H]5[C@@H](CS4)NC(=O)N5

Biotin-PEG6-Thalidomide（Cat No.:I015731）is a multifunctional chemical probe that combines biotin for avidin/streptavidin binding with thalidomide, a ligand for cereblon (CRBN) in targeted protein degradation studies. The PEG6 spacer provides hydrophilicity, flexibility, and optimal distance to minimize steric hindrance while maintaining binding efficiency. This construct enables the formation of PROTAC-like molecules for studying ubiquitin-mediated protein degradation, facilitating pull-down assays, or affinity enrichment. Its design supports high solubility and stability in biological systems, making it a valuable tool for chemical biology, drug discovery, and targeted protein research.