Biotin-PEG4-Alkyne

• CAT Number: L010072
• CAS Number: 1262681-31-1
• Molecular Formula: C21H35N3O6S
• Molecular Weight: 457.60
• Purity: ≥95%
• IUPAC Name: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl]pentanamide
• InChI: InChI=1S/C21H35N3O6S/c1-2-8-27-10-12-29-14-15-30-13-11-28-9-7-22-19(25)6-4-3-5-18-20-17(16-31-18)23-21(26)24-20/h1,17-18,20H,3-16H2,(H,22,25)(H2,23,24,26)/t17-,18-,20-/m0/s1
• InChIKey: SKMJWNZZFUDLKQ-BJLQDIEVSA-N
• SMILES: C#CCOCCOCCOCCOCCNC(=O)CCCC[C@H]1[C@@H]2[C@H](CS1)NC(=O)N2

Biotin-PEG4-Alkyne（Cat No.:L010072）is a bifunctional reagent combining biotin, a polyethylene glycol (PEG4) spacer, and a terminal alkyne group. The biotin moiety enables strong, specific binding to avidin or streptavidin, commonly used in affinity purification, labeling, and detection assays. The PEG4 spacer enhances solubility and reduces steric hindrance, improving accessibility in biological environments. The alkyne group allows for bioorthogonal conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) “click” chemistry. This versatile compound is widely used in chemical biology, proteomics, and drug discovery for targeted labeling, imaging, and bioconjugation applications.