Biotin-PEG2-C2-iodoacetamide

• CAT Number: I015732
• CAS Number: 292843-75-5
• Molecular Formula: C18H31IN4O5S
• Molecular Weight: 542.43
• Purity: ≥95%
• Synonyms: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[(2-iodoacetyl)amino]ethoxy]ethoxy]ethyl]pentanamide
• InChI: InChI=1S/C18H31IN4O5S/c19-11-16(25)21-6-8-28-10-9-27-7-5-20-15(24)4-2-1-3-14-17-13(12-29-14)22-18(26)23-17/h13-14,17H,1-12H2,(H,20,24)(H,21,25)(H2,22,23,26)/t13-,14-,17-/m0/s1
• InChIKey: LWGLKVINXNMNJX-ZQIUZPCESA-N
• SMILES: C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)NCCOCCOCCNC(=O)CI)NC(=O)N2

Biotin-PEG2-C2-iodoacetamide（Cat No.:I015732）is a heterobifunctional reagent combining biotin for high-affinity avidin/streptavidin binding with an iodoacetamide group for selective alkylation of thiols. The PEG2-C2 spacer improves hydrophilicity, flexibility, and reduces steric hindrance, ensuring efficient reactivity in both aqueous and organic systems. This design enables stable covalent attachment of biomolecules while maintaining biotin’s strong affinity interactions. Widely used in protein labeling, affinity purification, and probe development, Biotin-PEG2-C2-iodoacetamide provides a versatile tool for chemical biology, proteomics, and advanced bioconjugation applications requiring controlled and reliable functionalization.