Biotin-hexanamide-(L-Thyroxine)

• CAT Number: I040509
• CAS Number: 2278192-78-0
• Molecular Formula: C31H36I4N4O7S
• Molecular Weight: 1116.32
• Purity: ≥95%
• Synonyms: (2S)-2-[6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoylamino]-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
• InChI: InChI=1S/C31H36I4N4O7S/c32-18-13-17(14-19(33)28(18)42)46-29-20(34)10-16(11-21(29)35)12-22(30(43)44)37-26(41)8-2-1-5-9-36-25(40)7-4-3-6-24-27-23(15-47-24)38-31(45)39-27/h10-11,13-14,22-24,27,42H,1-9,12,15H2,(H,36,40)(H,37,41)(H,43,44)(H2,38,39,45)/t22-,23-,24-,27-/m0/s1
• InChIKey: JJYXTZZHRVXYDU-TTZMFTMZSA-N
• SMILES: C1C2C(C(S1)CCCCC(=O)NCCCCCC(=O)NC(CC3=CC(=C(C(=C3)I)OC4=CC(=C(C(=C4)I)O)I)I)C(=O)O)NC(=O)N2

Biotin-hexanamide-(L-Thyroxine)(CAT: I040509) is a conjugated molecule that combines L-thyroxine, a key thyroid hormone, with a biotin tag via a hexanamide linker. This hybrid structure allows for targeted biochemical applications where thyroid hormone signaling intersects with affinity-based detection or capture methods. The biotin moiety enables high-affinity binding to streptavidin or avidin systems, making the compound ideal for use in receptor binding assays, hormone transport studies, or as a probe in proteomics and cell imaging. The hexanamide spacer provides optimal flexibility and bioavailability. Supplied in high purity, this bioconjugate is valuable for endocrine research and assay development.

Reference

[1]. Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323.
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