BIO8898

• CAT Number: I042394
• Molecular Formula: C53H64N8O6
• Molecular Weight: 909.13
• Purity: ≥95%
• Synonyms: (2S)-2-cyclohexyl-2-[[4-[2-[(3-phenylphenyl)methylcarbamoyl]-6-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]pyridin-4-yl]-6-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]pyridine-2-carbonyl]amino]acetic acid
• InChI: InChI=1S/C53H64N8O6/c62-49(54-33-36-14-11-19-39(28-36)37-15-3-1-4-16-37)44-29-40(31-46(55-44)51(64)60-26-12-20-42(60)34-58-22-7-8-23-58)41-30-45(50(63)57-48(53(66)67)38-17-5-2-6-18-38)56-47(32-41)52(65)61-27-13-21-43(61)35-59-24-9-10-25-59/h1,3-4,11,14-16,19,28-32,38,42-43,48H,2,5-10,12-13,17-18,20-27,33-35H2,(H,54,62)(H,57,63)(H,66,67)/t42-,43-,48-/m0/s1
• InChIKey: WJYLSDLKLWXYML-CHQPKSDDSA-N
• SMILES: C1CCC(CC1)C(C(=O)O)NC(=O)C2=NC(=CC(=C2)C3=CC(=NC(=C3)C(=O)N4CCCC4CN5CCCC5)C(=O)NCC6=CC(=CC=C6)C7=CC=CC=C7)C(=O)N8CCCC8CN9CCCC9

BIO8898 (Cat No.: I042394) is a small molecule inhibitor that selectively targets the CD40–CD40L (CD154) protein–protein interaction, a critical pathway in immune cell activation and inflammatory signaling. By disrupting CD40L binding, BIO8898 modulates B cell and T cell responses, making it a valuable research tool in studying autoimmune diseases, transplant rejection, and chronic inflammation. It helps explore therapeutic strategies for conditions driven by aberrant CD40 signaling. BIO8898 is instrumental in advancing immunology research and the development of targeted immune-modulating therapies.

Reference

[1]. Silvian LF, et al. Small molecule inhibition of the TNF family cytokine CD40 ligand through a subunit fracture mechanism. ACS Chem Biol. 2011 Jun 17;6(6):636-47.
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