BIO

• CAT Number: I004510
• CAS Number: 667463-62-9
• Molecular Formula: C₁₆H₁₀BrN₃O₂
• Molecular Weight: 356.17
• Purity: ≥95%
• Target: GSK-3
• Solubility: DMSO: ≥ 23 mg/mL
• Storage: 2-8°C
• IC50: 5 nM(GSK-3α/β); 20 nM(CDK1-cyclinB) [1][2]
• IUPAC Name: 6-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol
• InChI: InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18-19,21H
• InChIKey: SAQUSDSPQYQNBG-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=CC(=C4)Br)O)N=O

BIO (Cat No.:I004510) is a specific GSK-3 inhibitor, acting on GSK-3α/ The IC50 of β is 5 nM, more than 16 times more selective than CDK5, and it is also a pan-JAK inhibitor with IC50 value of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells.

Reference

[1]. Polychronopoulos P, et al. Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J Med Chem. 2004 Feb 12;47(4):935-46.
[2]. Meijer L, et al. Pharmacological inhibitors of glycogen synthase kinase 3. Trends Pharmacol Sci. 2004 Sep;25(9):471-80.