For research use only. Not for therapeutic Use.
BIO-32546 (CAT: I016693) is a highly potent autotaxin (ATX) modulator with an IC₅₀ of 1 nM. Autotaxin, a secreted lysophospholipase D, catalyzes the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a bioactive lipid mediator involved in cell proliferation, migration, fibrosis, and tumor progression. By selectively inhibiting ATX, BIO-32546 serves as a valuable tool for probing LPA signaling pathways and their roles in cancer, fibrosis, and inflammatory diseases. Its high potency and stereospecific activity make it an attractive reference compound in drug discovery and biomedical research focused on ATX–LPA axis modulation.
| CAS Number | 1548743-66-3 |
| Synonyms | 8-[(1S)-1-[8-(trifluoromethyl)-7-[4-(trifluoromethyl)cyclohexyl]oxynaphthalen-2-yl]ethyl]-8-azabicyclo[3.2.1]octane-3-carboxylic acid |
| Molecular Formula | C28H31F6NO3 |
| Purity | ≥95% |
| IUPAC Name | 8-[(1S)-1-[8-(trifluoromethyl)-7-[4-(trifluoromethyl)cyclohexyl]oxynaphthalen-2-yl]ethyl]-8-azabicyclo[3.2.1]octane-3-carboxylic acid |
| InChI | InChI=1S/C28H31F6NO3/c1-15(35-20-7-8-21(35)13-18(12-20)26(36)37)17-3-2-16-4-11-24(25(23(16)14-17)28(32,33)34)38-22-9-5-19(6-10-22)27(29,30)31/h2-4,11,14-15,18-22H,5-10,12-13H2,1H3,(H,36,37)/t15-,18?,19?,20?,21?,22?/m0/s1 |
| InChIKey | PZASAAIJIFDWSB-CKPDSHCKSA-N |
| SMILES | CC(C1=CC2=C(C=C1)C=CC(=C2C(F)(F)F)OC3CCC(CC3)C(F)(F)F)N4C5CCC4CC(C5)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
