BIMU 8

• CAT Number: M106984
• CAS Number: 134296-40-5
• Molecular Formula: C19H26ClN4O2-
• Molecular Weight: 377.89
• Purity: ≥95%
• Synonyms: N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-3-propan-2-ylbenzimidazole-1-carboxamide;chloride
• InChI: InChI=1S/C19H26N4O2.ClH/c1-12(2)22-16-6-4-5-7-17(16)23(19(22)25)18(24)20-13-10-14-8-9-15(11-13)21(14)3;/h4-7,12-15H,8-11H2,1-3H3,(H,20,24);1H/p-1/t13?,14-,15+
• InChIKey: NQYXXIUVFVOJCX-XZPOUAKSSA-M
• SMILES: CC(C)N1C2=CC=CC=C2N(C1=O)C(=O)NC3CC4CCC(C3)N4C.[Cl-]

BIMU 8 (Cat No.: M106984) is a selective agonist of the 5-HT4 serotonin receptor, studied for its ability to enhance neurotransmission and gastrointestinal motility. By stimulating 5-HT4 receptors, BIMU 8 promotes acetylcholine release, influencing gut contractility and central nervous system signaling. Researchers use it to explore potential therapeutic strategies for gastrointestinal disorders, memory enhancement, and neurodegenerative diseases. Though not clinically developed, BIMU 8 remains an important pharmacological tool in neuroscience and gastroenterology research, helping clarify the roles of 5-HT4 receptor pathways in health and disease.

Reference

[1]. C Ghelardini, et al. Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8. Life Sci. 1996;58(25):2297-309.
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[2]. Lucie P Pellissier, et al. Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol Pharmacol. 2009 Apr;75(4):982-90.
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[3]. H Pan , et al. 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. Am J Physiol. 1994 Feb;266(2 Pt 1):G230-8.
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