Bicyclo[1.1.1]pentan-1-amine hydrochloride

• CAT Number: L036924
• CAS Number: 22287-35-0
• Molecular Formula: C5H10ClN
• Molecular Weight: 119.59
• Purity: ≥95%
• IUPAC Name: bicyclo[1.1.1]pentan-1-amine;hydrochloride
• InChI: InChI=1S/C5H9N.ClH/c6-5-1-4(2-5)3-5;/h4H,1-3,6H2;1H
• InChIKey: LQKLVOWNBKJRJE-UHFFFAOYSA-N
• SMILES: C1C2CC1(C2)N.Cl

Bicyclo[1.1.1]pentan-1-amine hydrochloride（Cat No.:L036924）is a crystalline salt form of a strained bicyclic amine, with the formula C5H10ClN. The bicyclo[1.1.1]pentane (BCP) core imparts rigidity and high ring strain, making it a popular bioisostere for phenyl or tert-butyl groups in medicinal chemistry. The primary amine allows for versatile derivatization, while the hydrochloride form improves solubility and stability. This compound is widely used in drug design and material science for enhancing metabolic stability, modifying molecular geometry, and introducing conformational constraint in target molecules. It is a key building block in modern synthetic chemistry.