(-)-Bicuculline methobromide（Cat No.:I001713）is a quaternary ammonium salt derivative of bicuculline, a competitive antagonist of GABAA_A receptors. By blocking GABA-mediated inhibitory neurotransmission, it increases neuronal excitability and induces convulsant activity, making it a standard tool in neuropharmacology. The methobromide form, being less lipophilic, restricts blood–brain barrier penetration, allowing more controlled experimental applications. It is commonly used in electrophysiological studies to dissect inhibitory signaling, synaptic plasticity, and excitatory–inhibitory balance in the central nervous system. This compound remains valuable for exploring GABAergic function in epilepsy and neurobiology research.