For research use only. Not for therapeutic Use.
BI-9321 trihydrochloride(CAT: I017235) is a potent, selective, and cell-active antagonist of the nuclear receptor-binding SET domain 3 (NSD3) PWWP1 domain, with a Kd of 166 nM. It shows high specificity, remaining inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 trihydrochloride disrupts NSD3-PWWP1 domain–histone interactions with an IC₅₀ of 1.2 μM in U2OS cells. Targeting the methyl-lysine binding site, it demonstrates sub-micromolar in vitro potency and effective cellular engagement at 1 μM. As a single agent, BI-9321 trihydrochloride downregulates Myc mRNA expression and suppresses proliferation in MOLM-13 cells, making it a valuable tool for studying NSD3-driven oncogenic pathways.
| CAS Number | 2387510-87-2 |
| Synonyms | [4-[5-(7-fluoroquinolin-4-yl)-1-methylimidazol-4-yl]-3,5-dimethylphenyl]methanamine;trihydrochloride |
| Molecular Formula | C22H24Cl3FN4 |
| Purity | ≥95% |
| IUPAC Name | [4-[5-(7-fluoroquinolin-4-yl)-1-methylimidazol-4-yl]-3,5-dimethylphenyl]methanamine;trihydrochloride |
| InChI | InChI=1S/C22H21FN4.3ClH/c1-13-8-15(11-24)9-14(2)20(13)21-22(27(3)12-26-21)18-6-7-25-19-10-16(23)4-5-17(18)19;;;/h4-10,12H,11,24H2,1-3H3;3*1H |
| InChIKey | DCDXMBVQCRHZMW-UHFFFAOYSA-N |
| SMILES | CC1=CC(=CC(=C1C2=C(N(C=N2)C)C3=C4C=CC(=CC4=NC=C3)F)C)CN.Cl.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
