BI-6901

• CAT Number: I023358
• CAS Number: 2040401-92-9
• Molecular Formula: C23H27N5O3S
• Molecular Weight: 453.56
• Purity: ≥95%
• Synonyms: N-[(2R)-4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-1H-indole-4-sulfonamide
• InChI: InChI=1S/C23H27N5O3S/c1-17-8-13-28(14-9-17)23(29)21(10-15-27-12-3-4-18(27)16-24)26-32(30,31)22-6-2-5-20-19(22)7-11-25-20/h2-7,11-12,17,21,25-26H,8-10,13-15H2,1H3/t21-/m1/s1
• InChIKey: BRJXJOWXAFLRTE-OAQYLSRUSA-N
• SMILES: CC1CCN(CC1)C(=O)C(CCN2C=CC=C2C#N)NS(=O)(=O)C3=CC=CC4=C3C=CN4

BI-6901 (Cat No.: I023358) is a potent, selective small-molecule RORγt (retinoic acid receptor-related orphan receptor gamma t) inverse agonist developed by Boehringer Ingelheim for immunology and inflammation research. By inhibiting RORγt, BI-6901 suppresses Th17 cell differentiation and IL-17 cytokine production, key drivers of autoimmune pathology. It has been studied in preclinical models of psoriasis, rheumatoid arthritis, and inflammatory bowel disease, where it demonstrated strong immunomodulatory effects. BI-6901 serves as a valuable pharmacological tool for exploring nuclear receptor biology, T cell regulation, and novel immunotherapies.

Reference

[1]. Asitha Abeywardane, et al. N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283.
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