For research use only. Not for therapeutic Use.
BI-4020（Cat No.:I046072）is a highly selective inhibitor of SOS1, a guanine nucleotide exchange factor that activates RAS by facilitating GDP-GTP exchange. By blocking SOS1-mediated RAS activation, BI-4020 suppresses downstream MAPK signaling, a pathway frequently dysregulated in cancers. This compound is valuable for studying oncogenic RAS-driven mechanisms and for developing targeted therapies against tumors harboring KRAS mutations. BI-4020 offers strong potency, favorable pharmacokinetics, and specificity, making it a promising candidate for translational cancer research. Its inhibition of SOS1 provides a novel approach to modulating aberrant RAS signaling.
| CAS Number | 2664214-60-0 |
| Synonyms | (11R)-5,11,26-trimethyl-16-[(4-methylpiperazin-1-yl)methyl]-7-oxa-4,5,13,20,22,27-hexazapentacyclo[22.3.1.02,6.013,21.014,19]octacosa-1(27),2(6),3,14(19),15,17,20,24(28),25-nonaen-23-one |
| Molecular Formula | C30H38N8O2 |
| Purity | ≥95% |
| IUPAC Name | (11R)-5,11,26-trimethyl-16-[(4-methylpiperazin-1-yl)methyl]-7-oxa-4,5,13,20,22,27-hexazapentacyclo[22.3.1.02,6.013,21.014,19]octacosa-1(27),2(6),3,14(19),15,17,20,24(28),25-nonaen-23-one |
| InChI | InChI=1S/C30H38N8O2/c1-20-6-5-13-40-29-24(17-31-36(29)4)26-16-23(14-21(2)32-26)28(39)34-30-33-25-8-7-22(15-27(25)38(30)18-20)19-37-11-9-35(3)10-12-37/h7-8,14-17,20H,5-6,9-13,18-19H2,1-4H3,(H,33,34,39)/t20-/m1/s1 |
| InChIKey | AIQBYZOTCIQTGW-HXUWFJFHSA-N |
| SMILES | C[C@@H]1CCCOC2=C(C=NN2C)C3=NC(=CC(=C3)C(=O)NC4=NC5=C(N4C1)C=C(C=C5)CN6CCN(CC6)C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
