BI-0115（Cat No.:I023338）is a potent and selective small-molecule inhibitor of gasdermin D (GSDMD), a key effector protein in pyroptosis, an inflammatory form of programmed cell death. By blocking GSDMD pore formation in the cell membrane, BI-0115 prevents the release of proinflammatory cytokines such as IL-1β and IL-18, thereby suppressing excessive inflammation. This makes it a promising therapeutic candidate for treating autoinflammatory and autoimmune diseases driven by inflammasome activation. Preclinical studies highlight its efficacy in models of systemic inflammation, supporting further investigation into its role as an anti-pyroptotic and immunomodulatory agent.