BH3 hydrochloride（Cat No.:I045818）is a synthetic small-molecule derivative designed to mimic the BH3 domain of pro-apoptotic Bcl-2 family proteins. By competitively binding to anti-apoptotic proteins such as Bcl-2 and Bcl-xL, it disrupts protein–protein interactions that normally prevent apoptosis, thereby promoting programmed cell death. The hydrochloride salt form improves solubility and handling in experimental systems. BH3 hydrochloride is widely used in cancer and apoptosis research to study mitochondrial pathway regulation, drug resistance, and the development of targeted therapeutics aimed at restoring apoptotic sensitivity in tumor cells.