For research use only. Not for therapeutic Use.
Bezuclastinib（Cat No.:I045117）is an investigational oral tyrosine kinase inhibitor selectively targeting KIT D816V and related mutations, which are key drivers in systemic mastocytosis and certain gastrointestinal stromal tumors (GIST). By inhibiting mutant KIT signaling, Bezuclastinib reduces mast cell proliferation and survival, offering a targeted approach for diseases with KIT-driven pathology. It is designed to minimize off-target effects, enhancing tolerability and safety. Bezuclastinib is being evaluated in clinical trials for advanced systemic mastocytosis and other KIT-altered cancers. Supplied for research on KIT inhibition, mast cell disorders, and precision oncology.
| CAS Number | 1616385-51-3 |
| Synonyms | 4,5-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide |
| Molecular Formula | C19H17N5O |
| Purity | ≥95% |
| IUPAC Name | 4,5-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide |
| InChI | InChI=1S/C19H17N5O/c1-11-12(2)23-24-17(11)19(25)21-15-8-14-9-16(22-18(14)20-10-15)13-6-4-3-5-7-13/h3-10H,1-2H3,(H,20,22)(H,21,25)(H,23,24) |
| InChIKey | NVSHVYGIYPBTEZ-UHFFFAOYSA-N |
| SMILES | CC1=C(NN=C1C(=O)NC2=CN=C3C(=C2)C=C(N3)C4=CC=CC=C4)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
