For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Betaine is used to treat homocystinuria.<br>Target: Others<br>Betaine exerts its isostabilizing effect without appreciably altering the conformation of double-stranded DNA from the B form. The presence of > 5 M betaine also does not greatly change the behavior of DNA as a polyelectrolyte; this lack of effect on electrostatic interactions is expected because betaine exists as a zwitterion near neutral pH [1]. Betaine improves the co-amplification of the two alternatively spliced variants of the prostate-specific membrane antigen mRNA as well as the amplification of the coding cDNA region of c-jun. It is suggested that betaine improves the amplification of these genes by reducing the formation of secondary structure caused by GC-rich regions and, therefore, may be generally applicable to ameliorate the amplification of GC-rich DNA sequences [2].<br></p>
| Catalog Number | I000342 |
| CAS Number | 107-43-7 |
| Molecular Formula | C5H11NO2 |
| Purity | ≥95% |
| Target | Others |
| Solubility | 10 mM in DMSO |
| Storage | 3 years -20C powder |
| Reference | <p style=/line-height:25px/> <br>[2]. Henke, W., et al., Betaine improves the PCR amplification of GC-rich DNA sequences. Nucleic Acids Res, 1997. 25(19): p. 3957-8. </p> |
