Benzaldehyde-PEG4-azide

• CAT Number: I016247
• CAS Number: 1151451-77-2
• Molecular Formula: C15H21N3O5
• Molecular Weight: 323.34
• Purity: ≥95%
• Synonyms: 4-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]benzaldehyde
• InChI: InChI=1S/C15H21N3O5/c16-18-17-5-6-20-7-8-21-9-10-22-11-12-23-15-3-1-14(13-19)2-4-15/h1-4,13H,5-12H2
• InChIKey: MJNGKISXZKKSNN-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C=O)OCCOCCOCCOCCN=[N+]=[N-]

Benzaldehyde-PEG4-azide(CAT: I016247) is a heterobifunctional PEG-based linker bearing a benzaldehyde group and a terminal azide, separated by a four-unit polyethylene glycol (PEG4) spacer. The benzaldehyde moiety enables oxime ligation or hydrazone bond formation with aminooxy- or hydrazide-containing molecules, offering chemoselective conjugation under mild conditions. The azide group allows bioorthogonal click chemistry via copper-catalyzed (CuAAC) or strain-promoted cycloaddition (SPAAC) with alkynes. The PEG4 spacer enhances solubility, flexibility, and biocompatibility, minimizing steric interference in biological systems. Benzaldehyde-PEG4-azide is widely applied in the synthesis of inhibitors, antibody–drug conjugates, and targeted imaging probes in cancer, immunology, and metabolic disease research.