For research use only. Not for therapeutic Use.
Benazepril(CAT: I005202) is an angiotensin-converting enzyme (ACE) inhibitor (C₂₄H₂₈N₂O₅) used to treat hypertension, heart failure, and certain kidney disorders. It is administered orally as a prodrug and is hydrolyzed in the liver to its active metabolite, benazeprilat, which inhibits ACE, thereby reducing the conversion of angiotensin I to angiotensin II—a potent vasoconstrictor. This leads to vasodilation, reduced blood pressure, and decreased workload on the heart. Benazepril is valued for its long duration of action, allowing once-daily dosing, and is often prescribed alone or in combination with other antihypertensive agents. Common side effects include cough, dizziness, and, rarely, hyperkalemia or angioedema.
| CAS Number | 86541-75-5 |
| Synonyms | 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid |
| Molecular Formula | C24H28N2O5 |
| Purity | ≥95% |
| IUPAC Name | 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid |
| InChI | InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1 |
| InChIKey | XPCFTKFZXHTYIP-PMACEKPBSA-N |
| SMILES | CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
