For research use only. Not for therapeutic Use.
BCN-SS-NHS（Cat No.:I045946）is a cleavable, heterobifunctional linker designed for bioorthogonal conjugation and controlled release applications. It features a bicyclononyne (BCN) group that undergoes strain-promoted azide–alkyne cycloaddition (SPAAC), enabling rapid, copper-free click chemistry with azides under mild conditions. The central disulfide (SS) bond provides a redox-sensitive cleavage site, allowing reversible linkage and controlled release in reducing environments. The NHS ester reacts efficiently with primary amines on proteins, peptides, or polymers, forming stable amide bonds. This reagent is highly useful in chemical biology, drug delivery, proteomics, and diagnostic research.
| Synonyms | (2,5-dioxopyrrolidin-1-yl) 3-[2-[[(1S,8R)-9-bicyclo[6.1.0]non-4-ynyl]methoxycarbonylamino]ethyldisulfanyl]propanoate |
| Molecular Formula | C20H26N2O6S2 |
| Purity | ≥95% |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
