BCN-PEG4-hydrazide

• CAT Number: I045953
• Molecular Formula: C22H37N3O7
• Molecular Weight: 455.55
• Purity: ≥95%
• Synonyms: [(1R,8S)-9-bicyclo[6.1.0]non-4-ynyl]methyl N-[2-[2-[2-[2-(3-hydrazinyl-3-oxopropoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate
• IUPAC Name: [(1S,8R)-9-bicyclo[6.1.0]non-4-ynyl]methyl N-[2-[2-[2-[2-(3-hydrazinyl-3-oxopropoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate
• InChI: InChI=1S/C22H37N3O7/c23-25-21(26)7-9-28-11-13-30-15-16-31-14-12-29-10-8-24-22(27)32-17-20-18-5-3-1-2-4-6-19(18)20/h18-20H,3-17,23H2,(H,24,27)(H,25,26)/t18-,19+,20?
• InChIKey: IYCQJGJIYDHELJ-YOFSQIOKSA-N
• SMILES: C1CC2C(C2COC(=O)NCCOCCOCCOCCOCCC(=O)NN)CCC#C1

BCN-PEG4-hydrazide(CAT: I045953) is a heterobifunctional linker incorporating a strained bicyclo[6.1.0]nonyne (BCN) moiety and a terminal hydrazide group, connected via a four-unit polyethylene glycol (PEG4) spacer. The BCN group enables rapid, copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) with azide-containing biomolecules, providing highly selective and bioorthogonal conjugation. The hydrazide functionality allows efficient coupling with aldehydes and ketones to form stable hydrazone linkages. The PEG4 spacer improves aqueous solubility, reduces steric hindrance, and enhances biocompatibility. BCN-PEG4-hydrazide is particularly valuable for site-specific labeling, inhibitor synthesis, and antibody–drug conjugates in cancer, immunology, and metabolic disease research where dual reactivity and precision are essential.