BCL6-IN-6

• CAT Number: I044163
• CAS Number: 2408882-54-0
• Molecular Formula: C27H31FN6O2S
• Molecular Weight: 522.64
• Purity: ≥95%
• Synonyms: 5-(cyclopenten-1-yl)-N-[4-[[2-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-5-fluoropyrimidin-4-yl]amino]-2-methoxyphenyl]thiophene-2-carboxamide
• IUPAC Name: 5-(cyclopenten-1-yl)-N-[4-[[2-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-5-fluoropyrimidin-4-yl]amino]-2-methoxyphenyl]thiophene-2-carboxamide
• InChI: InChI=1S/C27H31FN6O2S/c1-16-14-34(15-17(2)30-16)27-29-13-20(28)25(33-27)31-19-8-9-21(22(12-19)36-3)32-26(35)24-11-10-23(37-24)18-6-4-5-7-18/h6,8-13,16-17,30H,4-5,7,14-15H2,1-3H3,(H,32,35)(H,29,31,33)/t16-,17+
• InChIKey: VJFKSXHAFLCLLP-CALCHBBNSA-N
• SMILES: C[C@@H]1CN(C[C@@H](N1)C)C2=NC=C(C(=N2)NC3=CC(=C(C=C3)NC(=O)C4=CC=C(S4)C5=CCCC5)OC)F

BCL6-IN-6（Cat No.:I044163）is a selective small-molecule inhibitor targeting B-cell lymphoma 6 (BCL6), a transcriptional repressor implicated in the development and progression of certain lymphoid malignancies, including diffuse large B-cell lymphoma (DLBCL). By disrupting BCL6’s interaction with corepressor complexes, BCL6-IN-6 reactivates the expression of genes involved in apoptosis and cell cycle arrest. This leads to reduced tumor cell proliferation and enhanced sensitivity to chemotherapeutic agents. BCL6-IN-6 is a valuable tool in cancer research, used to explore the therapeutic potential of BCL6 inhibition and the underlying molecular mechanisms driving BCL6-dependent oncogenesis.