BC-DXI-843

• CAT Number: I015198
• CAS Number: 2421117-98-6
• Molecular Formula: C28H26N4O4S2
• Molecular Weight: 546.66
• Purity: ≥95%
• Synonyms: (2S)-3-(1H-indol-3-yl)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]propanamide
• InChI: InChI=1S/C28H26N4O4S2/c1-18-7-13-22(14-8-18)38(34,35)32-25(15-20-16-29-24-6-4-3-5-23(20)24)27(33)31-28-30-26(17-37-28)19-9-11-21(36-2)12-10-19/h3-14,16-17,25,29,32H,15H2,1-2H3,(H,30,31,33)/t25-/m0/s1
• InChIKey: VLPGAOXBMXGNGM-VWLOTQADSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)NC4=NC(=CS4)C5=CC=C(C=C5)OC

BC-DXI-843（Cat No.:I015198）is a potent and selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), a serine/threonine kinase implicated in neuronal development, cell cycle regulation, and disease pathology. DYRK1A overexpression has been linked to Down syndrome, neurodegenerative disorders, and certain cancers. By blocking DYRK1A activity, BC-DXI-843 serves as a valuable chemical probe for dissecting kinase-driven signaling pathways and evaluating therapeutic strategies. Its specificity makes it suitable for exploring roles of DYRK1A in neurobiology, oncology, and metabolism, providing insights into targeted drug discovery.