For research use only. Not for therapeutic Use.
BAY-8400 (Cat No.: I045390) is an investigational small-molecule inhibitor targeting chemokine receptor CXCR4, a receptor involved in cell migration, hematopoiesis, and tumor metastasis. Overexpression of CXCR4 is associated with cancer progression, immune evasion, and poor prognosis in various malignancies. By blocking CXCR4 signaling, BAY-8400 impairs tumor cell trafficking, reduces metastatic potential, and enhances immune cell infiltration into tumors. It is primarily used in preclinical and early clinical studies to evaluate its therapeutic potential in oncology and hematologic malignancies, including leukemia and multiple myeloma.
| CAS Number | 2763602-59-9 |
| Synonyms | 8-[5-(difluoromethyl)pyridin-3-yl]-1-(2,3,6,7-tetrahydrooxepin-4-yl)-[1,2,4]triazolo[4,3-a]quinoxaline |
| Molecular Formula | C21H17F2N5O |
| Purity | ≥95% |
| InChI | InChI=1S/C21H17F2N5O/c22-20(23)16-8-15(10-24-11-16)14-3-4-17-18(9-14)28-19(12-25-17)26-27-21(28)13-2-1-6-29-7-5-13/h2-4,8-12,20H,1,5-7H2 |
| InChIKey | ATKHYZXUMVNCIO-UHFFFAOYSA-N |
| SMILES | C1COCCC(=C1)C2=NN=C3N2C4=C(C=CC(=C4)C5=CC(=CN=C5)C(F)F)N=C3 |
| Reference | [1]. Berger M, et al. BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies [published online ahead of print, 2021 Aug 24]. J Med Chem. 2021;10.1021/acs.jmedchem.1c00762. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
