For research use only. Not for therapeutic Use.
BAY-707(CAT: I017483) is a substrate-competitive, highly potent, and selective MTH1 (NUDT1) inhibitor with an IC50 of 2.3 nM. It demonstrates strong cellular target engagement (EC50 = 7.6 nM) and high permeability in Caco-2 assays, along with favorable physicochemical and pharmacokinetic properties, including high metabolic stability in human microsomes and rat hepatocytes. Orally administered in mice (50–250 mg/kg), BAY-707 is well tolerated with minimal toxicity. Despite robust biochemical potency, BAY-707 shows no significant antiproliferative or anticancer efficacy in vitro or in vivo, making it a valuable tool compound for mechanistic studies of MTH1 biology and DNA repair pathways.
| CAS Number | 2109805-96-9 |
| Synonyms | N-ethyl-4-[(3S)-3-methylmorpholin-4-yl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide |
| Molecular Formula | C15H20N4O2 |
| Purity | ≥95% |
| IUPAC Name | N-ethyl-4-[(3S)-3-methylmorpholin-4-yl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide |
| InChI | InChI=1S/C15H20N4O2/c1-3-16-15(20)12-8-11-13(4-5-17-14(11)18-12)19-6-7-21-9-10(19)2/h4-5,8,10H,3,6-7,9H2,1-2H3,(H,16,20)(H,17,18)/t10-/m0/s1 |
| InChIKey | RPMGXDCRCWWCRY-JTQLQIEISA-N |
| SMILES | CCNC(=O)C1=CC2=C(C=CN=C2N1)N3CCOCC3C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
