BAY-678 racemate

• CAT Number: I019765
• CAS Number: 675103-35-2
• Molecular Formula: C₂₀H₁₅F₃N₄O₂
• Molecular Weight: 400.35
• Purity: ≥95%
• Target: Elastase

BAY-678 racemate(CAT: I019765), also known as the racemic form of BAY-678, is a compound that exhibits similar properties to BAY-678. BAY-678 is a highly potent and selective inhibitor of human neutrophil elastase (HNE), an enzyme involved in inflammatory processes. BAY-678 demonstrates an IC50 value of 20 nM, indicating its strong inhibitory activity against HNE. It is orally bioavailable and has the ability to permeate cells. BAY-678 has been recognized as a chemical probe by the Structural Genomics Consortium (SGC), contributing to its potential use as a research tool for studying HNE-related processes and diseases.

Reference

[1]. von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73.