For research use only. Not for therapeutic Use.
BAY-6035（Cat No.:I015061）is a potent and selective small-molecule inhibitor of the receptor-interacting protein kinase 1 (RIPK1), a critical regulator of necroptosis and inflammation. By blocking RIPK1 activity, BAY-6035 prevents programmed necrosis and associated inflammatory responses, making it highly useful for investigating regulated cell death mechanisms. Researchers employ BAY-6035 to study pathways involved in neurodegeneration, autoimmune diseases, and inflammatory disorders, as well as its potential therapeutic relevance in cancer. Its selectivity and strong pharmacological profile make it a valuable tool for dissecting RIPK1-mediated signaling events.
| CAS Number | 2247890-13-5 |
| Synonyms | (2S)-1-(3-azabicyclo[3.1.0]hexane-3-carbonyl)-N-(2-cyclopropylethyl)-2-methyl-4-oxo-3,5-dihydro-2H-1,5-benzodiazepine-7-carboxamide |
| Molecular Formula | C22H28N4O3 |
| Purity | ≥95% |
| IUPAC Name | (2S)-1-(3-azabicyclo[3.1.0]hexane-3-carbonyl)-N-(2-cyclopropylethyl)-2-methyl-4-oxo-3,5-dihydro-2H-1,5-benzodiazepine-7-carboxamide |
| InChI | InChI=1S/C22H28N4O3/c1-13-8-20(27)24-18-10-15(21(28)23-7-6-14-2-3-14)4-5-19(18)26(13)22(29)25-11-16-9-17(16)12-25/h4-5,10,13-14,16-17H,2-3,6-9,11-12H2,1H3,(H,23,28)(H,24,27)/t13-,16?,17?/m0/s1 |
| InChIKey | CKFRXCBNKKOFGO-IGEOTXOUSA-N |
| SMILES | C[C@H]1CC(=O)NC2=C(N1C(=O)N3CC4CC4C3)C=CC(=C2)C(=O)NCCC5CC5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
