For research use only. Not for therapeutic Use.
BAY 60-2770(CAT: I017238) is a potent, selective, and orally bioavailable activator of soluble guanylyl cyclase (sGC). Unlike nitric oxide-dependent stimulators, BAY 60-2770 activates sGC independently of NO, leading to enhanced cGMP signaling. It exhibits notable antifibrotic activity, with oral administration (0.1–0.3 mg/kg) effectively attenuating liver fibrosis in two rat models. Additionally, BAY 60-2770 (1 mg/kg, p.o.) administered daily from weeks 10 to 12 improves bladder dysfunction in high-fat obese mice. By targeting sGC in a unique manner, BAY 60-2770 provides a valuable pharmacological tool for studying fibrotic disease mechanisms and NO-independent cGMP modulation in metabolic and inflammatory disorders.
| CAS Number | 1027642-43-8 |
| Synonyms | 4-[[4-carboxybutyl-[2-[5-fluoro-2-[[4-[4-(trifluoromethyl)phenyl]phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid |
| Molecular Formula | C35H33F4NO5 |
| Purity | ≥95% |
| IUPAC Name | 4-[[4-carboxybutyl-[2-[5-fluoro-2-[[4-[4-(trifluoromethyl)phenyl]phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid |
| InChI | InChI=1S/C35H33F4NO5/c36-31-16-17-32(45-23-25-6-8-26(9-7-25)27-12-14-30(15-13-27)35(37,38)39)29(21-31)18-20-40(19-2-1-3-33(41)42)22-24-4-10-28(11-5-24)34(43)44/h4-17,21H,1-3,18-20,22-23H2,(H,41,42)(H,43,44) |
| InChIKey | CRQMDXFUKDWARU-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1CN(CCCCC(=O)O)CCC2=C(C=CC(=C2)F)OCC3=CC=C(C=C3)C4=CC=C(C=C4)C(F)(F)F)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
