For research use only. Not for therapeutic Use.
BAY 41-8543（Cat No.:I004004）is a pharmacological stimulator of soluble guanylate cyclase (sGC), an enzyme that plays a critical role in the nitric oxide (NO) signaling pathway. By directly activating sGC independently of NO, BAY 41-8543 enhances cyclic GMP (cGMP) production, leading to vasodilation and improved blood flow. It has been studied for therapeutic applications in cardiovascular diseases, including pulmonary hypertension and heart failure. BAY 41-8543 helps relax vascular smooth muscle, reduce vascular resistance, and improve hemodynamics, making it a promising candidate for treating conditions involving impaired NO signaling or endothelial dysfunction.
| CAS Number | 256498-66-5 |
| Synonyms | 2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine |
| Molecular Formula | C21H21FN8O |
| Purity | ≥95% |
| IUPAC Name | 2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine |
| InChI | InChI=1S/C21H21FN8O/c22-15-6-2-1-4-13(15)12-30-21-14(5-3-7-25-21)16(28-30)20-26-18(23)17(19(24)27-20)29-8-10-31-11-9-29/h1-7H,8-12H2,(H4,23,24,26,27) |
| InChIKey | AQYFUZRYBJBAGZ-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=C(N=C(N=C2N)C3=NN(C4=C3C=CC=N4)CC5=CC=CC=C5F)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
