For research use only. Not for therapeutic Use.
BAY 2476568（Cat No.:I044534）is a selective small-molecule inhibitor of the transcription factor TEAD (TEA domain family), which plays a crucial role in the Hippo signaling pathway. This pathway regulates cell proliferation, apoptosis, and organ size, and its dysregulation is implicated in various cancers. BAY 2476568 interferes with TEAD’s palmitoylation, a modification essential for its transcriptional activity, thereby blocking downstream oncogenic gene expression driven by YAP/TAZ coactivators. It is being explored in preclinical and clinical studies as a targeted cancer therapy, particularly for tumors exhibiting aberrant Hippo-YAP/TAZ signaling activity.
| CAS Number | 2311901-93-4 |
| Synonyms | 3-(3-fluoro-2-methoxyanilino)-2-[3-(2-methoxy-2-methylpropoxy)pyridin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one |
| Molecular Formula | C24H27FN4O4 |
| Purity | ≥95% |
| IUPAC Name | 3-(3-fluoro-2-methoxyanilino)-2-[3-(2-methoxy-2-methylpropoxy)pyridin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one |
| InChI | InChI=1S/C24H27FN4O4/c1-24(2,32-4)13-33-18-12-26-10-8-14(18)20-21(19-16(28-20)9-11-27-23(19)30)29-17-7-5-6-15(25)22(17)31-3/h5-8,10,12,28-29H,9,11,13H2,1-4H3,(H,27,30) |
| InChIKey | ZOEVXMKZJWZLFX-UHFFFAOYSA-N |
| SMILES | CC(C)(COC1=C(C=CN=C1)C2=C(C3=C(N2)CCNC3=O)NC4=C(C(=CC=C4)F)OC)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
