For research use only. Not for therapeutic Use.
BAY 1892005(CAT: I040524) is a novel small-molecule regulator of the p53 protein, specifically designed to modulate p53 condensates without reactivating mutant p53 function. It exhibits antiproliferative effects in cancer cell lines harboring mutant p53, such as Huh7 and H358, with IC₅₀ values of 11.2 μM and 11.1 μM, respectively. BAY 1892005 offers a unique mechanism of action by targeting the physical state and compartmentalization of p53, rather than its transcriptional activity. This makes it a promising tool for studying non-canonical p53 signaling and developing alternative therapeutic strategies for p53-mutant cancers. Supplied in high purity for oncology and molecular biology research.
| CAS Number | 2036352-13-1 |
| Synonyms | 2-chloro-N-[4-(2-fluorophenyl)-1,3-thiazol-2-yl]acetamide |
| Molecular Formula | C11H8ClFN2OS |
| Purity | ≥95% |
| IUPAC Name | 2-chloro-N-[4-(2-fluorophenyl)-1,3-thiazol-2-yl]acetamide |
| InChI | InChI=1S/C11H8ClFN2OS/c12-5-10(16)15-11-14-9(6-17-11)7-3-1-2-4-8(7)13/h1-4,6H,5H2,(H,14,15,16) |
| InChIKey | JYANOVDYYBXVNL-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C(=C1)C2=CSC(=N2)NC(=O)CCl)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
