BAY 11-7082- CAS 19542-67-7

BAY 11-7082 is an irreversible inhibitor of IKKα and phosphorylation of cytokine-inducible IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-α, NFKBIA; IC50=10 μM).
IC50 value: 10 μM
Target: IκBa phosphorylation
in vitro: Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Bay 11-7082 rapidly and efficiently reduces the DNA binding of NF-κB in HTLV-I-infected T-cell lines and down-regulates the expression of the antiapoptotic gene, Bcl-xL, regulated by NF-κB. [1] BAY 11-7082 inhibits the loading of ubiquitin on to E2 conjugating enzymes [2] BAY 11-7082 is an IKK inhibitor poorly selective for IKK1 and IKK2.[3]

Catalog Number: I002493

CAS Number: 19542-67-7

PubChem Substance ID:355145986

Molecular Formula: C10H9NO2S

Molecular Weight:207.247

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms(E)-3-(4-methylphenyl)sulfonylprop-2-enenitrile

Property

Molecular Formula: C10H9NO2S
Molecular Weight207.247
Target:IκB/IKK
Solubility10 mM in DMSO
Purity≥95%
Storage3 years -20C powder
MDLMFCD00712162
IC5010 μM

Computed Descriptor

IUPAC Name(E)-3-(4-methylphenyl)sulfonylprop-2-enenitrile
InChIInChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
InChIKeyDOEWDSDBFRHVAP-KRXBUXKQSA-N
SMILESCC1=CC=C(C=C1)S(=O)(=O)C=CC#N