BAX-IN-1

• CAT Number: I040518
• CAS Number: 331261-91-7
• Molecular Formula: C16H14N6O
• Molecular Weight: 306.32
• Purity: ≥95%
• Synonyms: N-[(E)-1-(5-methylfuran-2-yl)ethylideneamino]-5H-[1,2,4]triazino[5,6-b]indol-3-amine
• InChI: InChI=1S/C16H14N6O/c1-9-7-8-13(23-9)10(2)19-21-16-18-15-14(20-22-16)11-5-3-4-6-12(11)17-15/h3-8H,1-2H3,(H2,17,18,21,22)/b19-10+
• InChIKey: YOMZPGUGBDWVTQ-VXLYETTFSA-N
• SMILES: CC1=CC=C(O1)C(=NNC2=NC3=C(C4=CC=CC=C4N3)N=N2)C

BAX-IN-1(CAT: I040518) is a potent and selective small-molecule inhibitor of Bcl-2-associated X protein (BAX), a key pro-apoptotic regulator in the intrinsic mitochondrial apoptosis pathway. By binding to BAX, BAX-IN-1 prevents its conformational activation, oligomerization, and subsequent mitochondrial membrane permeabilization, thereby inhibiting apoptosis. This compound is especially valuable for studying BAX-mediated cell death mechanisms in contexts such as neurodegeneration, ischemic injury, and immune regulation. BAX-IN-1 also serves as a tool for distinguishing BAX-specific apoptotic processes from other Bcl-2 family pathways. Supplied in high purity, BAX-IN-1 is ideal for cell biology, apoptosis research, and therapeutic development targeting mitochondrial integrity.