BAP9THP

• CAT Number: I045545
• CAS Number: 2312-73-4
• Molecular Formula: C17H19N5O
• Molecular Weight: 309.37
• Purity: ≥95%
• Synonyms: N-benzyl-9-(oxan-2-yl)purin-6-amine
• InChI: InChI=1S/C17H19N5O/c1-2-6-13(7-3-1)10-18-16-15-17(20-11-19-16)22(12-21-15)14-8-4-5-9-23-14/h1-3,6-7,11-12,14H,4-5,8-10H2,(H,18,19,20)
• InChIKey: POFWRMVFWIJXHP-UHFFFAOYSA-N
• SMILES: C1CCOC(C1)N2C=NC3=C(N=CN=C32)NCC4=CC=CC=C4

BAP9THP (Cat No.: I045545) is a synthetic chemical probe designed as an inhibitor of the histone methyltransferase G9a (EHMT2), a key epigenetic regulator of gene expression. By blocking G9a-mediated H3K9 methylation, BAP9THP reduces transcriptional repression and alters chromatin structure, enabling studies of epigenetic control, cancer biology, and neurobiology. It serves as a valuable research tool for dissecting the role of histone modifications in gene regulation, cellular differentiation, and disease progression, supporting drug discovery efforts in oncology and other therapeutic areas.

Reference

[1]. Smýkalová, I., et al. The effects of novel synthetic cytokinin derivatives and endogenous cytokinins on the in vitro growth responses of hemp (Cannabis sativa L.) explants. Plant Cell Tiss Organ Cult 139, 381–394 (2019).

[2]. Vylíčilová H, et al. Naturally Occurring and Artificial N9-Cytokinin Conjugates: From Synthesis to Biological Activity and Back. Biomolecules. 2020;10(6):832. Published 2020 May 29.
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