Bakkenolide A

• CAT Number: R072428
• CAS Number: 19906-72-0
• Molecular Formula: C15H22O2
• Molecular Weight: 234.33
• Purity: ≥95%
• Synonyms: (2R,3aR,7S,7aR)-7,7a-dimethyl-4′-methylidenespiro[3,3a,4,5,6,7-hexahydro-1H-indene-2,3′-oxolane]-2′-one
• IUPAC Name: (2R,3aR,7S,7aR)-7,7a-dimethyl-4'-methylidenespiro[3,3a,4,5,6,7-hexahydro-1H-indene-2,3'-oxolane]-2'-one
• InChI: InChI=1S/C15H22O2/c1-10-5-4-6-12-7-15(9-14(10,12)3)11(2)8-17-13(15)16/h10,12H,2,4-9H2,1,3H3/t10-,12+,14+,15+/m0/s1
• InChIKey: OVXAYHNZXBOVPV-QMGNLALYSA-N
• SMILES: C[C@H]1CCC[C@H]2[C@@]1(C[C@]3(C2)C(=C)COC3=O)C

Bakkenolide A（Cat No.:R072428）is a sesquiterpene lactone isolated from Petasites tricholobus and related Petasites species, plants long used in traditional medicine. It is structurally characterized by a guaianolide skeleton and exhibits notable anti-inflammatory, antitumor, and neuroprotective activities. Research shows that Bakkenolide A can inhibit pro-inflammatory cytokines, modulate NF-κB signaling, and suppress cancer cell proliferation while inducing apoptosis. Additionally, its neuroprotective potential suggests benefits against neurodegenerative conditions. With its diverse bioactivities, Bakkenolide A is considered a promising natural compound for therapeutic research in oncology and inflammatory diseases.