For research use only. Not for therapeutic Use.
Azvudine(CAT: I003894) is an oral nucleoside analog antiviral that acts as a reverse transcriptase inhibitor, effectively disrupting viral RNA synthesis. Initially developed for the treatment of HIV-1 infection, it is phosphorylated intracellularly into its active triphosphate form, which incorporates into viral RNA and induces chain termination. Beyond its role in HIV therapy, Azvudine has also been evaluated and conditionally approved in China for treating COVID-19, reflecting its broad-spectrum antiviral activity. With favorable oral bioavailability and targeted mechanism of action, Azvudine provides a valuable research tool for studying viral replication pathways and the development of next-generation antiviral therapeutics.
| CAS Number | 1011529-10-4 |
| Synonyms | 4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
| Molecular Formula | C9H11FN6O4 |
| Purity | ≥95% |
| IUPAC Name | 4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
| InChI | InChI=1S/C9H11FN6O4/c10-5-6(18)9(3-17,14-15-12)20-7(5)16-2-1-4(11)13-8(16)19/h1-2,5-7,17-18H,3H2,(H2,11,13,19)/t5-,6-,7+,9+/m0/s1 |
| InChIKey | KTOLOIKYVCHRJW-XZMZPDFPSA-N |
| SMILES | C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
