Azumolene

• CAT Number: I022953
• CAS Number: 64748-79-4
• Molecular Formula: C13H9BrN4O3
• Molecular Weight: 349.14
• Purity: ≥95%
• Synonyms: 1-[(E)-[5-(4-bromophenyl)-1,3-oxazol-2-yl]methylideneamino]imidazolidine-2,4-dione
• InChI: InChI=1S/C13H9BrN4O3/c14-9-3-1-8(2-4-9)10-5-15-12(21-10)6-16-18-7-11(19)17-13(18)20/h1-6H,7H2,(H,17,19,20)/b16-6+
• InChIKey: SEGCNGONCZQFDW-OMCISZLKSA-N
• SMILES: C1C(=O)NC(=O)N1N=CC2=NC=C(O2)C3=CC=C(C=C3)Br

Azumolene (Cat No.: I022953) is a hydantoin derivative and water-soluble analog of dantrolene that acts as a ryanodine receptor type 1 (RyR1) antagonist. By inhibiting abnormal calcium release from the sarcoplasmic reticulum in skeletal muscle, it reduces excitation–contraction coupling and prevents calcium overload. Azumolene has been investigated for the treatment of malignant hyperthermia and muscle contracture disorders, offering advantages over dantrolene due to its higher solubility and easier formulation. It is a valuable research tool for studying calcium signaling and RyR1-mediated physiology.

Reference

[1]. G C Leslie, et al. The effect of EU4093 (azumolene sodium) on the contraction of intrafusal muscle in the soleus muscle of the anaesthetized rat. Br J Pharmacol. 1989 Aug;97(4):1151-6.
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[2]. Viktor Yarotskyy, et al. Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death. PLoS One. 2013 Oct 15;8(10):e77633.
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