For research use only. Not for therapeutic Use.
Azoxymethane (AOM) (Cat No.: I020341) is a potent carcinogenic chemical widely used in research to induce colon cancer in animal models. As a DNA alkylating agent, AOM metabolizes into methylazoxymethanol (MAM), leading to DNA mutations and tumor formation, particularly in the colon. It is a valuable tool for studying colorectal cancer mechanisms, tumorigenesis, and chemopreventive strategies. AOM-induced models help evaluate the efficacy of anti-cancer drugs, dietary interventions, and genetic factors involved in colorectal cancer progression and therapeutic development.
| CAS Number | 25843-45-2 |
| Molecular Formula | C₂H₆N₂O |
| Purity | ≥95% |
| Target | Cell Cycle/DNA Damage |
| IUPAC Name | methyl-methylimino-oxidoazanium |
| InChI | 1S/C2H6N2O/c1-3-4(2)5/h1-2H3 |
| InChIKey | DGAKHGXRMXWHBX-UHFFFAOYSA-N |
| SMILES | CN=[N+](C)[O-] |
| Reference | [1]. Megaraj V, et al. Role of hepatic and intestinal p450 enzymes in the metabolic activation of the colon carcinogen azoxymethane in mice. Chem Res Toxicol. 2014 Apr 21;27(4):656-62.<br>[2]. Whetstone RD, et al. Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate. Mol Carcinog. 2016 Jul;55(7):1187-95. |
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