Azido-PEG8-Boc

• CAT Number: I016946
• CAS Number: 1623791-99-0
• Molecular Formula: C23H45N3O10
• Molecular Weight: 523.62
• Purity: ≥95%
• Synonyms: tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C23H45N3O10/c1-23(2,3)36-22(27)4-6-28-8-10-30-12-14-32-16-18-34-20-21-35-19-17-33-15-13-31-11-9-29-7-5-25-26-24/h4-21H2,1-3H3
• InChIKey: LBNCLZBCQUTBAP-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]

Azido-PEG8-Boc(CAT: I016946) is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal azide group and a Boc-protected amine separated by an eight-unit PEG spacer. The azide moiety enables efficient copper-catalyzed or strain-promoted azide–alkyne cycloaddition (“click chemistry”), while the Boc-protected amine provides an orthogonal reactive site for selective deprotection and subsequent coupling to acids or activated esters. The PEG8 chain imparts excellent solubility, hydrophilicity, and flexibility, minimizing steric hindrance in conjugation reactions. Azido-PEG8-Boc is a versatile building block for bioconjugation, PROTAC development, drug delivery systems, and surface functionalization, where dual reactivity and extended linker length are advantageous.