Azido-PEG3-SS-NHS

• CAT Number: I045947
• Molecular Formula: C15H24N4O7S2
• Molecular Weight: 436.50
• Purity: ≥95%
• Synonyms: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyldisulfanyl]propanoate
• InChI: InChI=1S/C15H24N4O7S2/c16-18-17-4-5-23-6-7-24-8-9-25-10-12-28-27-11-3-15(22)26-19-13(20)1-2-14(19)21/h1-12H2
• InChIKey: GULGJNLQJQCHEW-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCSSCCOCCOCCOCCN=[N+]=[N-]

Azido-PEG3-SS-NHS（Cat No.:I045947）is a cleavable, heterobifunctional linker designed for efficient and versatile bioconjugation. It features an azide group that undergoes copper-catalyzed or strain-promoted click chemistry with alkynes, enabling rapid and selective modification. The PEG3 spacer enhances solubility, reduces steric hindrance, and provides flexibility in complex biomolecular systems. The disulfide (SS) bond introduces a redox-sensitive cleavage site, allowing controlled release under reducing conditions. The NHS ester reacts efficiently with primary amines on proteins, peptides, or polymers, forming stable amide linkages. This reagent is valuable in chemical biology, proteomics, drug delivery, and diagnostic research.