AZD9898

For research use only. Not for therapeutic Use.

  • CAT Number: I018084
  • CAS Number: 2042347-69-1
  • Molecular Formula: C20H19ClF3N3O4
  • Molecular Weight: 457.83
  • Purity: ≥95%
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AZD9898(Cat No.:I018084)is an inhaled, selective DP2_2 (CRTH2) receptor antagonist developed to target inflammatory pathways in respiratory diseases. By blocking prostaglandin D2_2-mediated signaling, it reduces activation and migration of eosinophils, basophils, and Th2 lymphocytes, key drivers of airway inflammation. Designed for local delivery to the lungs, AZD9898 minimizes systemic exposure while enhancing therapeutic efficacy. It has been investigated in asthma and other allergic airway disorders as a potential treatment to improve lung function, decrease inflammation, and provide better control of symptoms in patients with Th2-driven disease.


CAS Number 2042347-69-1
Synonyms

(1S,2S)-2-[5-(5-chloro-2,4-difluoro-N-(2-fluoro-2-methylpropyl)anilino)-3-methoxypyrazine-2-carbonyl]cyclopropane-1-carboxylic acid

Molecular Formula C20H19ClF3N3O4
Purity ≥95%
IUPAC Name trans-(1S,2S)-2-[5-(5-chloro-2,4-difluoro-N-(2-fluoro-2-methylpropyl)anilino)-3-methoxypyrazine-2-carbonyl]cyclopropane-1-carboxylic acid
InChI InChI=1S/C20H19ClF3N3O4/c1-20(2,24)8-27(14-5-11(21)12(22)6-13(14)23)15-7-25-16(18(26-15)31-3)17(28)9-4-10(9)19(29)30/h5-7,9-10H,4,8H2,1-3H3,(H,29,30)/t9-,10-/m0/s1
InChIKey RVMWIVNHZMXEHS-UWVGGRQHSA-N
SMILES CC(C)(CN(C1=CC(=C(C=C1F)F)Cl)C2=CN=C(C(=N2)OC)C(=O)[C@H]3C[C@@H]3C(=O)O)F
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