For research use only. Not for therapeutic Use.
AZD7325(CAT: I003793) is a potent, orally active, and selective positive allosteric modulator (PAM) of the GABAAreceptor system. It exhibits high binding affinity at the α2 (Ki_i=0.3 nM) and α3 (Ki_i=1.3 nM) subtypes, while showing reduced efficacy at α1 and α5 receptors (Ki_i=0.5 and 230 nM, respectively). In vitro, AZD7325 acts as a moderate CYP1A2 inducer and a potent CYP3A4 inducer. Preclinical studies demonstrate its ability to attenuate hyperthermia-induced seizures and modulate anxiety-related pathways. AZD7325 is a valuable research tool for investigating GABAergic signaling, anxiety disorders, and epilepsy models such as Dravet syndrome.
| CAS Number | 942437-37-8 |
| Synonyms | 4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide |
| Molecular Formula | C19H19FN4O2 |
| Purity | ≥95% |
| IUPAC Name | 4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide |
| InChI | InChI=1S/C19H19FN4O2/c1-3-10-22-19(25)18-16(21)12-7-4-6-11(17(12)23-24-18)15-13(20)8-5-9-14(15)26-2/h4-9H,3,10H2,1-2H3,(H2,21,23)(H,22,25) |
| InChIKey | KYDURMHFWXCKMW-UHFFFAOYSA-N |
| SMILES | CCCNC(=O)C1=NN=C2C(=C1N)C=CC=C2C3=C(C=CC=C3F)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
